Florence is a great home base when visiting Italy. In the heart of Tuscany, it's close to so many other interesting cities that can easily be explored in a day. Some effort is required to get to this charming hilltop town but it is well worth it.
In the heart of Tuscany, lies beautiful Siena. This hilly town is home to a magnificent Duomo and iconic Tuscan delicacies (think panforte and pici pasta.) It deserves to be on your list of must-see places in Italy and is easy to visit in just a day.